Metabolism of vinyl chloride
Web1 apr. 1992 · The initial step in vinyl chloride metabolism in strain L1 is catalyzed by alkene monooxygenase, transforming vinyl chloride into the reactive epoxide … WebEnvironmental Health Perspectives Vol. 17, pp. 217-219, 1976 Studiesonthe Metabolism of Vinyl Chloride byH. Antweiler* Vinyl chloride (VCM) is not carcinogenic by itself. it is …
Metabolism of vinyl chloride
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Web8 mrt. 2016 · Vinyl chloride (VC) is an organochlorine used to create the polymer, polyvinyl chloride. VC is ranked as the 4th most important toxic chemical on the Hazardous … Webvinyl chloride were used in preliminary experiments with TA 1535. A water solution of vinyl chloride was prepared by bubbling vinyl chloride gas through water in a test tube for a …
Web21 mrt. 2003 · The metabolism of vinyl chloride in the presence of oxygen may proceed via two possible mechanisms. In one pathway, VC serves as a primary substrate for … WebVinyl chloride is thought to depress the CNS via a solvent effect on lipids and protein components of neural membranes that interrupts signal transmission. Reactive metabolic intermediates may also cause specific target organ toxicity by covalently bonding to tissue or initiating destructive chain reactions such as lipid peroxidation.
WebChloroacetaldehyde is a metabolite in the degradation of 1,2-dichloroethane, which initially converts to chloroethanol. This metabolic pathway is topical because 1,2-dichloroethane is produced on a large as a precursor to vinyl chloride. [8] Safety [ edit] Chloroacetaldehyde is corrosive to mucous membranes. Web24 mrt. 2007 · Vinyl chloride (VC) is a human carcinogen known to undergo metabolism by cytochrome P450 2E1 (CYP2E1) to reactive intermediates that can cause oncogene …
WebSemantic Scholar extracted view of "Vinylchloride metabolism — A review" by H. Plugge et al. Skip to search form Skip to main content Skip to account menu. Semantic Scholar's …
Web1 dec. 2009 · Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to … black fruit bowlWebVinyl Chloride H2C=CHCl or C2H3Cl CID 6338 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … black frp wall linerWebFirst-order kinetics describes the metabolism of VC up to about 200 mg/m3. The metabolism is believed to proceed through the micro-somal mixed-function oxidase system, forming chloroethylene oxide which rapidly rearranges to chloroacetaldehyde (11). … black fruit bowl amazonWebChloroethylene mixtures Pharmacokinetic modeling and/n vitro metabolism of vinyl chloride, trichloroethylene, and tranv-l,2-dichloroethylene in rats. Toxicol Appl … black fruit bowl with banana hangerWeb9 feb. 2024 · It is well known that the risk for developing chronic liver injury is influenced by multiple factors, such as genetics, comorbidities, and/or lifestyle choices, such as diet. 12 Obesity is a major problem in the United States, with over 68% of the population obese (BMI ≥30). 11, 13 Nonalcoholic fatty liver disease (NAFLD) is the major hepatic manifestation … gameshow frankfurtWeb1 okt. 1976 · The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. … black fruit bowl /20cmWebR.J. Preston, J.A. Ross, in Comprehensive Toxicology, 2010 1.16.3.5 Halogenated Hydrocarbons. Occupational exposure to vinyl chloride is associated with a high … gameshow games archive.org